Ad ID: 67002
Sale Price: $2500
Condition: Brand New
Location: United Kingdom
Phone: +86 186 2556 5096
Buy JWH-018 Online
Buy JWH-018 online JWH-018 seen as synthetic cannabinoid found in several versions of the herbal mixture “Spice.”
The Illicit use of these Spice cannabinoids centers on its mind effects which imitate those of Δ9-THC in cannabis.
Thus, while considerably more potent than similar amounts of cannabis,
JWH-018 also exhibits significant challenges for detection by specific Δ9-THC testing assays.
In July 2009, JWH-018 saw itself listed on the drug and chemical list of concern by the US Drug Enforcement Agency (DEA).
In addition to reported seizures of JWH-018 in Ohio and Florida, several states have passed legislative action restricting the sale or possession of JWH-018.
JWH-018 for sale
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The recreational use of synthetic cannabinoids has recently increased. This increase is due, in part, to the recent availability of inexpensive compound sold legally online in bulk. In particular, JWH-018 (1-pentyl-3-(1-naphthoyl)indole) and JWH-073 (1-butyl-3-(1-naphthoyl)indole) have been found in herbal blends marketed as alternatives to cannabis. Although these particular compounds have recently been emergency scheduled in the United States, online suppliers have shifted sales to other, similar compounds that are not currently scheduled. However, the purity of the drugs obtained from online suppliers is not known. Relative purity of JWH-018 and JWH-073 from three different online suppliers was determined using high-performance liquid chromatography with ultraviolet detection and validated standards obtained from a traditional research chemical supplier. Our results show that JWH-018 and JWH-073 obtained from online vendors was of comparable purity to validated standards, even though the physical properties varied in color, texture, and odor. It is concluded that adverse events following consumption of synthetic cannabinoid preparations is unlikely to be due to impurities or residue from the manufacturing process, but rather to effects of the active drug or interactions with other psychoactive chemicals from herbs blended into products marketed as cannabis alternatives. Buy JWH-018 Online
The recreational use of synthetic cannabinoids has increased over the past several years. In particular, several aminoindoles have gained worldwide popularity due to the prevalence of online suppliers (1, 2). Until recently, these compounds were sold with no legal restrictions in the United States. Recently, however, the United States Drug Enforcement Agency (DEA) listed five such compounds as emergency scheduled substances (3, 4). Following that decision, the DEA was required to file a Notice of Intent to allow distributors at least 30 days to eliminate all remaining stocks of these substances. During that time, online retailers encouraged customers to stockpile the chemicals in anticipation of the end of legal sales. In the case of one supplier, 100 g of complimentary drug was added to randomly selected orders placed over December 15–17, 2010. Buy JWH-018 Online
Two of the recently scheduled drugs are JWH-018 [1-pentyl-3-(1-naphthoyl)indole] and JWH-073 [1-butyl-3-(1-naphthoyl)indole]. These drugs have been identified in herbal blends that are sold as legal alternatives to marijuana (5). Furthermore, these drugs have been linked to side effects that required medical attention in recreational users (6, 7).
Suppliers purport to provide drugs with greater than 99% purity, yet provide no documentation in support of these claims, either online or included as a certificate of analysis with the shipment. Thus, it would be of interest to know the relative purity of the chemicals that are almost certainly being diverted to recreational street use. Impurities left from the manufacturing process could account for toxicities reported by some users, and here we address this possibility. We report the purity and some physical characteristics of JWH-018 and JWH-073 obtained from several different sources. Drug purchased from Cayman Chemical (Ann Arbor, MI), certified as being ≥ 98% pure, represented the standard against which samples obtained from three different online suppliers (one Chinese and two domestic sources) were compared. Samples were analyzed using high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection in an assay optimized for cannabinoids (8). Buy JWH-018 Online
JWH-018 and JWH-073 (≥ 98% purity) were purchased from Cayman Chemical Company and used as the standards against which the purity of JWH-018 or JWH-073 from the online sources was evaluated. JWH-018 was also obtained from three different, non-traditional, online sources: yanlingresearchchemicallab.com [Newport Beach, CA, Source #1]; yanlingresearchchemicallab.com [Scottsdale, AZ, Source #2]; and IU Chem Holding Co., Ltd [Shanghai, China, Source #3]. Both yanlingresearchchemicallab.com and yanlingresearchchemicallab.com purport to be domestic companies with products synthesized in the United States, though no domestic contact is currently listed on either website, and the domain registration for Research Chemical Supplier may be a proxy for an international company. Drug from each of the other sources was ordered online, with no minimum age requirement or limitations on amount purchased. Δ9-Tetrahydrocannabinol (Δ9-THC) was obtained from the National Institute on Drug Abuse (Rockville, MD) and used as an internal standard for the quantification of JWH-018 and JWH-073; it was also used as an aid for identification of the other compounds, which were identified by relative elution time. Also, RCS-4, JWH-250, JWH-081 pure standards were purchased from Cayman Chemical to test for the specificity of the chromatographic system for JWH-018 and JWH-073. Finally, JWH-018 was purchased from Sigma-Aldrich (St. Louis, MO) for observation of physical properties and chromatographic purposes.
Each powdered drug sample was characterized in terms of color, texture, and odor. A primary stock solution of 1 mg/mL was prepared by dissolving drug in methanol. Aliquots of the primary stock solution were stored at –80°C. On the day of each experiment, an aliquot of the primary stock solution was diluted with mobile phase to attain working stock solutions that were injected into the HPLC system. Primary stock and working stock solutions were tested on at least two separate occasions. Buy JWH-018 Online
The HPLC system consisted of a Waters model 515 pump, a Waters model 717 autosampler, a Waters model 2487 UV detector, and a Grace C18 column (5 µm, 4.6-mm i.d. × 150 mm). The mobile phase consisted of either 65% (v/v) or 95% (v/v) acetonitrile and 10 mM potassium phosphate buffer using Milli-Q water (pH 2.5). The flow rate of the mobile phase was 0.5 mL/min. UV detection was performed at a fixed wavelength of 220 nm.
Validation of the HPLC assay
The analytical range of calibrators for both JWH-018 and JWH-073 (Cayman standards) dissolved in mobile phase was 31.3 to 5000 ng/mL. For JWH-018 and JWH-073, the limits of detection (LOD) were 2.93 and 1.93 ng/mL, respectively, and the limits of quantification (LOQ) were 9.76 and 6.44 ng/mL, respectively. The LOD and LOQ were determined as the concentrations that could be detected at 3 and 10 times background noise, respectively. Precision and accuracy of the assay for JWH-018 at 1000 ng/mL were 3.4% and 99.6%, respectively. Precision and accuracy of the assay for JWH-073 at 1000 ng/mL were 2.0% and 98.3%, respectively.
Analysis and purity calculation
Working drug solutions for JWH-018 and JWH-073 from online sources were prepared at a concentration of 1000 ng/mL and quantified using analytical range calibrator curves of Cayman standards on two separate occasions. Purity of JWH-018 and JWH-073 from each non-traditional, online source was expressed as a percentage of the expected concentration.
Characteristics of drug obtained from each source are shown in Table I. JWH-018 and JWH-073 from different sources varied substantially in color, texture, and odor. Color ranged from white (JWH-018 from Sigma) to dark brown (JWH-018 from Source #2). Texture ranged from a fine powder (JWH-018 from Source #3) to a chunky powder (JWH-018 from Sigma) to a plastic or resin (JWH-018 from Source #2) to a gel (JWH-018 from Source #1). The odor of naphthalene was present for JWH-018 samples from Source #2 and Source #3. Dissolving drug from each supplier in methanol, then evaporating the solvent resulted in drug that was similar in appearance (white), texture (chunky powder), and odor (none) across all suppliers.
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